|
KMID : 1239920150090050472
|
|
Nutrition Research and Practice
2015 Volume.9 No. 5 p.472 ~ p.479
|
|
|
Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice
|
|
Park Mi-Hwa
Nam Young-Hwa
Han Ji-Sook
|
|
|
Abstract
|
|
|
BACKGROUND/OBJECTIVES:The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice.
MATERIALS/METHODS:For 6 weeks, male C57BL/KsJ-db/db mice were administrated SCE (0.5%, w/w), and rosiglitazone (0.005%, w/w).
RESULTS:A supplement of the SCE for 6 weeks induced a significant reduction in blood glucose and glycosylated hemoglobin concentrations, and it improved hyperinsulinemia compared to the diabetic control db/db mice. The glucokinase activity in the hepatic glucose metabolism increased in the SCE-supplemented db/db mice, while phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities in the SCE-supplemented db/db mice were significantly lower than those in the diabetic control db/db mice. The homeostatic index of insulin resistance was lower in the SCE-supplemented db/db mice than in the diabetic control db/db mice.
CONCLUSIONS:These results suggest that a supplement of the SCE lowers the blood glucose concentration by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance.
|
|
|
KEYWORD
|
|
|
Anti-diabetic effects, Sargassum coreanum extract, C57BL/KsJ-db/db mice, hyperglycemia, insulin resistance
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|