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KMID : 1239920180120020160
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Nutrition Research and Practice
2018 Volume.12 No. 2 p.160 ~ p.165
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Associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans
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Kim Sung-Hee
Park Yeong-Mi
Choi Bo-Youl
Kim Mi-Kyung
Roh Sung-Won
Kim Kyung-A
Yang Yoon-Jung
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Abstract
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BACKGROUND/OBJECTIVES: Korea is quickly becoming an aged society. Dementia is also becoming a vital public health problem in Korea. Cognitive impairment as a pre-stage of dementia shares most risk factors for dementia. The aim of the present study was to determine associations of serum levels of vitamins A, C, and E with the risk of cognitive impairment among elderly Koreans.
SUBJECTS/METHODS: In this cross-sectional study, a total of 230 participants aged 60?79 years from Yangpyeong cohort were included. Cognitive function was assessed by the Korean version of the Mini-Mental State Examination for Dementia Screening. The logistic multivariable regression model was applied to determine the effect of serum vitamins A, C, and E on the risk of cognitive impairment.
RESULTS: There was no significant association between the risk of cognitive impairment and serum levels of vitamin A and vitamin C. There was a significant odd ratio when the second tertile group of beta-gamma tocopherol level was compared to the first tertile group [odds ratio (OR) = 0.37, 95% confidence interval (CI) = 0.14?0.98, P for trend = 0.051]. In subgroup analyses, there were significant negative associations between beta-gamma tocopherol level and the risk of cognitive impairment in men (OR = 0.17, 95% CI = 0.03?0.87, P for trend = 0.028), non-drinkers or former drinkers (OR = 0.13, 95% CI = 0.02?0.66, P for trend = 0.025), and non-smokers or former smokers (OR = 0.27, 95% CI = 0.09?0.82, P for trend = 0.017).
CONCLUSION: Serum beta-gamma tocopherol levels tended to be inversely associated with the risk of cognitive impairment. Further prospective large-scaled studies are needed to examine this association.
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KEYWORD
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Dementia, cognition, vitamin A, ascorbic acid, vitamin E
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