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KMID : 1239920180120050378
Nutrition Research and Practice
2018 Volume.12 No. 5 p.378 ~ p.386
Corni Fructus attenuates testosterone-induced benign prostatic hyperplasia by suppressing 5¥á-reductase and androgen receptor expression in rats
Hwangbo Hyun

Kwon Da-He
Choi Eun-Ok
Kim Min-Yeong
Ahn Kyu-Im
Ji Eun-Sun
Kim Jong-Sik
Kim Kyung-Il
Park No-Jin
Kim Bum-Hoi
Kim Gi-Young
Hong Su-Hyun
Park Cheol
Jeong Ji-Suk
Choi Yung-Hyun
Abstract
BACKGROUND/OBJECTIVES: Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention and treatment of various diseases because of its strong antioxidant effect, but its efficacy against BPH is not yet known. This study was designed to evaluate the therapeutic efficacy of Corni Fructus water extract (CF) in testosterone-induced BPH rats.

MATERIALS/METHODS: To induce BPH, rats were intraperitoneal injected with testosterone propionate (TP). Rats in the treatment group were orally administered with CF with TP injection, and finasteride, which is a selective inhibitor of 5¥á-reductase type 2, was used as a positive control.

RESULTS: Our results showed that the increased prostate weight and histopathological changes in BPH model rats were suppressed by CF treatment. CF, similar to the finasteride-treated group, decreased the levels of testosterone and dihydrotestosterone by TP treatment in the serum, and it also reduced 5¥á-reductase expression and concentration in prostate tissue and serum, respectively. In addition, CF significantly blocked the expression of the androgen receptor (AR), AR co-activators, and proliferating cell nuclear antigen in BPH rats, and this blocking was associated with a decrease in prostate-specific antigen levels in serum and prostate tissue.

CONCLUSIONS: These results suggest that CF may weaken the BPH status through the inactivation of at least 5¥á-reductase and AR activity and may be useful for the clinical treatment of BPH.
KEYWORD
Benign prostatic hyperplasia, corni fructus, dihydrotestosterone, androgen receptor, prostate-specific antigen
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