KMID : 1239920210150020173
|
|
Nutrition Research and Practice 2021 Volume.15 No. 2 p.173 ~ p.186
|
|
Effects of the fermented Zizyphus jujuba in the amyloid ¥â25-35-induced Alzheimer's disease mouse model
|
|
Kim Min-Jeong
Jung Ji-Eun Lee Sang-Hyun Cho Eun-Ju Kim Hyun-Young
|
|
Abstract
|
|
|
BACKGROUD/OBJECTIVES: Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Due to the increased incidence of dementia, there is a corresponding increase concerning the importance of AD. In this study, we investigated the protective effects conferred by Zizyphus jujuba (Zj) and Zizyphus jujuba fermented by yeast (Zj-Y), on cognitive impairment in an AD mouse model.
MATERIALS/METHODS: AD was induced by injecting amyloid beta25-35 (A¥â25-35) in ICR mice, and subsequently 200 mg/kg Zj or Zj-Y was administered daily for 14 days. The cognitive ability of AD mice was observed through behavioral experiments in T-maze, novel object recognition, and Morris water maze tests. We subsequently measured the levels of malondialdehyde (MDA), nitric oxide (NO), aspartate aminotransferase, and alanine aminotransferase in either tissues or serum.
RESULTS: In behavioral tests, deterioration was revealed in the short- and long-term learning and memory functions in the A¥â25-35-injected control group compared to the normal group, indicating that A¥â25-35 injection impairs cognitive functions. However, administration of Zj and Zj-Y improved cognitive function in mice, as compared to the A¥â25-35-injected control mice. In addition, the A¥â25-35 induced elevations of MDA and NO in the brain, kidney, and liver were suppressed after exposure to Zj and Zj-Y. Especially, Zj-Y showed stronger scavenging effect against MDA and NO, as compared to Zj.
CONCLUSIONS: Results of the present study indicate that Zj-Y exerts a protective effect on cognitive impairment and memory dysfunction, which is exerted by attenuating the oxidative stress induced by A¥â25-35.
|
|
KEYWORD
|
|
Alzheimer's disease, amyloid, fermentation, mice, ziziphus
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|