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KMID : 1239920230170050870
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Nutrition Research and Practice
2023 Volume.17 No. 5 p.870 ~ p.882
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Mentha canadensis attenuates adiposity and hepatic steatosis in high-fat diet-induced obese mice
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Han Young-Ji
Choi Ji-Young
Kwon Eun-Young
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Abstract
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BACKGROUND/OBJECTIVES : Obesity is a major risk factor for metabolic syndrome, a global public health problem. Mentha canadensis (MA), a traditional phytomedicine and dietary herb used for centuries, was the focus of this study to investigate its effects on obesity.
MATERIALS/METHODS : Thirty-five male C57BL/6J mice were randomly divided into 2 groups and fed either a normal diet (ND, n = 10) or a high-fat diet (HFD, n = 25) for 4 weeks to induce obesity. After the obesity induction period, the HFD-fed mice were randomly separated into 2 groups: one group continued to be fed HFD (n = 15, HFD group), while the other group was fed HFD with 1.5% (w/w) MA ethanol extract (n = 10, MA group) for 13 weeks.
RESULTS : The results showed that body and white adipose tissue (WAT) weights were significantly decreased in the MA-supplemented group compared to the HFD group. Additionally, MA supplementation enhanced energy expenditure, leading to improvements in plasma lipids, cytokines, hepatic steatosis, and fecal lipids. Furthermore, MA supplementation regulated lipid-metabolism-related enzyme activity and gene expression, thereby suppressing lipid accumulation in the WAT and liver.
CONCLUSIONS : These findings indicate that MA has the potential to improve diet-induced obesity and its associated complications, including adiposity, dyslipidemia, hepatic steatosis, and inflammation.
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KEYWORD
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Obesity, metabolic syndrome, herbal medicine, nonalcoholic fatty liver disease, diet, high-fat
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