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KMID : 1812020140200030371
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Journal of Neurogastroenterology and Motility
2014 Volume.20 No. 3 p.371 ~ p.378
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Normal Solid Gastric Emptying Values Measured by Scintigraphy Using Asian-style Meal:A Multicenter Study in Healthy Volunteers
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Abstract
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Background/Aims: To report gastric emptying scintigraphy, normal values should be established for a specific protocol. The aim of this study was to provide normal gastric emptying values and determine factors affecting gastric emptying using Asian rice-based meal in healthy volunteers.
Methods: One hundred and ninety-two healthy volunteers were included at 7 tertiary care centers across Thailand. Gastric emptying scintigraphy was acquired in 45 degree left anterior oblique view immediately after ingestion of a 267 kcal steamed-rice with technetium-99m labeled-microwaved egg meal with 100 mL water for up to 4 hours.
Results: One hundred and eighty-nine volunteers (99 females, age 43 ± 14 years) completed the study. The medians (5?95th percentiles) of lag time, gastric emptying half time (GE T1/2) and percent gastric retentions at 2 and 4 hours for all volunteers were 18.6 (0.5?39.1) minutes, 68.7 (45.1?107.8) minutes, 16.3% (2.7?49.8%) and 1.1% (0.2?8.8%), respectively. Female volunteers had significantly slower gastric emptying compared to male (GE T1/2, 74 [48?115] minutes vs. 63 (41?96) minutes; P < 0.05). Female volunteers who were in luteal phase of menstrual cycle had significantly slower gastric emptying compared to those in follicular phase or menopausal status (GE T1/2, 85 [66?102] mintes vs. 69 [50?120] minutes or 72 [47?109] minutes, P < 0.05). All of smoking volunteers were male. Smoker male volunteers had significantly faster gastric emptying compared to non-smoker males (GE T1/2, 56 [44?80] minutes vs. 67 [44?100] minutes, P < 0.05). Age, body mass index and alcohol consumption habits did not affect gastric emptying values.
Conclusions: A steamed-rice with microwaved egg meal was well tolerated by healthy volunteers. Gender, menstrual status and smoking status were found to affect solid gastric emptying.
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KEYWORD
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Gastric emptying, Healthy volunteers, Oryza sativa (Rice), Radionuclide imaging, Smoking
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