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KMID : 1812120230290010026
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Clinical Hypertension
2023 Volume.29 No. 1 p.26 ~ p.26
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Relationship between the methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP and serum homocysteine levels of Zhuang hypertensive patients in the central region of Guangxi
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Xi-Jiang Hu
Mei-Ru Su
Bao-Wei Cao
Fa-Bang Ou
Rui-Xing Yin
Jung Sang-Won
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Abstract
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Background : The relationship between the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphism (SNP) and serum homocysteine (Hcy) levels or H-type hypertension in different populations is inconsistent. This study aimed to explore the association between the MTHFR rs1801133 SNP and serum Hcy levels of Zhuang hypertensive patients in the central region of Guangxi.
Methods : A total of 606 Zhuang inpatients with essential hypertension were recruited in our hospital from August 2016 to December 2018. The patients were divided into H-type hypertension (Hcy?>?10 μmol/L, n?=?528) and non?H-type hypertension (Hcy?≤?10 μmol/L, n?=?78) groups. At the same time, an age- and sex-matched group of 379 subjects with normal physical examination in our hospital were selected as the control group. Blood biochemical measurements and genotyping of the MTHFR rs1801133 SNP were performed.
Results : The prevalence of H-type hypertension was 87.13%. The levels of serum Hcy in patients with hypertension were higher than those in control group (14.20?±?5.78 μmol/L vs. 11.97?±?5.39 μmol/L, P?
Conclusions : There was closely related between the MTHFR rs1801133 SNP and serum Hcy levels in Zhuang patients with H-type hypertension in the central region of Guangxi. The MTHFR SNP may be an important reason for the increase of serum Hcy levels in Zhuang patients with H-type hypertension in this region.
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KEYWORD
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Homocysteine, Hyperhomocysteinemia, H-type hypertension, Methylenetetrahydrofolate reductase, Single nucleotide polymorphism
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