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KMID : 1812320220390010003
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Journal of Yeungnam Medical Science
2022 Volume.39 No. 1 p.3 ~ p.11
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Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
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Chung Hyun-Uk
Son Jun-Hyuk
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Abstract
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Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of ‘salmon patch’, ocular adnexa lymphoma (OAL) should be suspected. Although the pathogenetic mechanism of ocular adnexal MALT lymphoma (OAML) is not yet fully understood, the relationship between OAML and Chlamydia psittaci has been hypothesized recently, similar to that between gastric MALT lymphoma and Helicobacter pylori. This suggests a new treatment option for OAML; bacterial eradication therapy with systemic antibiotics. Several other treatment methods for OAML have been introduced, but no treatment guidelines have been established yet. In this article, we summarize the current knowledge on the clinical features, pathogenesis, diagnostic methods, therapeutic strategies, and prognosis of OAML.
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KEYWORD
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Chlamydia psittaci, Etiology, Marginal zone B-cell lymphoma, Ocular adnexal lymphoma, Orbital neoplasms
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