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KMID : 1812320230400000037
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Journal of Yeungnam Medical Science
2023 Volume.40 No. 0 p.37 ~ p.46
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Diagnostic performance of F-18 FDG PET or PET/CT for detection of recurrent gastric cancer: a systematic review and meta-analysis
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Choi Chang-In
Park Jae-Kyun
Jeon Tae-Yong
Lee Soon-Hang
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Abstract
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Background : This systematic review and meta-analysis investigated the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for the detection of disease recurrence after curative resection of gastric cancer.
Methods : The PubMed and Embase databases, from the earliest available date of indexing through November 30, 2019, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT to detect recurrent disease after gastric cancer surgery.
Results : Across 17 studies (1,732 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.82 (95% confidence interval [CI], 0.74?0.88) with heterogeneity of I2=76.5 (p<0.001), and the specificity was 0.86 (95% CI, 0.78?0.91) with heterogeneity of I2=94.2 (p<0.001). Likelihood ratio (LR) tests gave an overall positive LR of 6.0 (95% CI, 3.6?9.7) and negative LR of 0.2 (95% CI, 0.14?0.31). The pooled diagnostic odds ratio was 29 (95% CI, 13?63). The summary receiver operating characteristic curve indicates that the area under the curve was 0.91 (95% CI, 0.88?0.93).
Conclusion : The current meta-analysis showed good sensitivity and specificity of F-18 FDG PET or PET/CT for detecting recurrent disease after curative resection of gastric cancer despite heterogeneity in ethnicity, recurrence rate, histology, and interpretation method.
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KEYWORD
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Diagnostic imaging, Fluorodeoxyglucose F18, Positron emission tomography computed tomography, Recurrence, Stomach neoplasms
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