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KMID : 1812320230400010023
Journal of Yeungnam Medical Science
2023 Volume.40 No. 1 p.23 ~ p.29
The use of animal models in rheumatoid arthritis research
Kong Jin-Sun

Jeong Gi-Heon
Yoo Seung-Ah
Abstract
The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response. Animal models have been established to study these pathological features of human RA. Spontaneous and induced animal models of RA primarily reflect inflammatory aspects of the disease. Among various induced animal models, collagen-induced arthritis (CIA) and collagen antibody-induced arthritis (CAIA) models are widely used to study the pathogenesis of RA. Improved transplantation techniques for severe combined immunodeficiency (SCID) mouse models of RA can be used to evaluate the effectiveness of potential therapeutics in human tissues and cells. This review provides basic information on various animal models of RA, including CIA and CAIA. In addition, we describe a SCID mouse coimplantation model that can measure the long-distance migration of human RA synoviocytes and cartilage destruction induced by these cells.
KEYWORD
Animal models, Cell movement, Rheumatoid arthritis, Severe combined immunodeficient mice, Synoviocytes
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