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KMID : 1813520150040010014
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Journal of the Korean Glaucoma Society
2015 Volume.4 No. 1 p.14 ~ p.20
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Spatial Contrast Sensitivity for the Diagnosis of Glaucoma
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Sung Mi-Sun
Park Sang-Woo
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Abstract
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Purpose : To investigate spatial-contrast sensitivity (SCS) assessment as a tool for the diagnosis of glaucoma.
Methods : Glaucoma (64 eyes), glaucoma suspect (62 eyes) and controls (80 eyes ) aged 30?76 years were randomly enrolled. Three groups were evaluated with Full-Threshold 30-2 program of the Humphrey Field Analyzer and monocular and binocular SCS using the Functional Acuity Contrast Test chart. The correlation between monocular SCS and the visual filed indexes (MD, PSD) were analyzed in patients with glaucoma and glaucoma suspect. The diagnostic power of SCS was assessed at each spatial frequency.
Results : Patients with glaucoma and glaucoma suspect showed significantly decreased SCS (p < 0.001 at 1.5, 3, 12, 18 c/d and p = 0.021 at 6 c/d) compared to controls. The correlation between MD and monocular SCS (R = 0.533, p < 0.001 at 1.5 c/d, R = 0.548, p < 0.001 at 3 c/d, R = 0.517, p < 0.001 at 6 c/d, R = 0.663, p < 0.001 at 12 c/d, R = 0.530, p < 0.001 at 18 c/d), and PSD and monocular SCS (R = ?0.579, p < 0.001 at 1.5 c/d, R = ?0.559, p < 0.001 at 3 c/d, R = ?0.575, p < 0.001 at 6 c/d, R = ?0.624, p < 0.001 at 12 c/d, R = ?0.610 at 18 c/d, p < 0.001) was significant in glaucoma. The correlation between PSD and monocular CSF was significant at 12 c/d and 18 c/d in glaucoma suspect (R = ?0.584, p < 0.001 at 12 c/d, R = ?0.605 at 18 c/d, p < 0.001). Largest AROC was obtained at 18 c/d spatial frequency for differentiating controls versus glaucoma and controls versus glaucoma suspect (AROC, 0.781, 0.751, respectively).
Conclusions : The impairment of SCS may be a useful psychophysical indicator for the diagnosis of glaucoma.
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KEYWORD
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Glaucoma, Preperimetric glaucoma, Contrast sensitivity, Visual field index
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