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KMID : 1813520150040010021
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Journal of the Korean Glaucoma Society
2015 Volume.4 No. 1 p.21 ~ p.26
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The Intraocular Pressure-lowering Effects of Bimatoprost/Timolol Fixed Combination Therapy for Glaucoma
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Shim Seong-Hee
Kim Sung-Ho
Kim Joon-Mo
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Abstract
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Purpose : To evaluate the effects of a bimatoprost/timolol fixed combination (BTFC) on intraocular pressure (IOP) and anterior ocular parameters in glaucoma.
Methods : We enrolled 21 glaucoma patients in this prospective clinical study. IOP was measured every 2 hours from 9:00 to 17:00 at baseline and 6 months later. Specular microscope value, corneal curvature, pupil diameter, anterior chamber depth, central cornea thickness were obtained. Adverse events were assessed by patient interview and by slit lamp examination.
Results : Mean diurnal IOP decreased 34.9% in open-angle glaucoma (OAG) patients and 27.6% in normal-tension glaucoma (NTG) patients. For anterior ocular parameters such as specular microscope value, corneal curvature, pupil diameter, anterior chamber depth, central cornea thickness at baseline and 6 months after BTFC treatment, there were no significant differences between the baseline and 6 momths values. The most frequently occurring adverse event with BTFC treatment was conjunctival hyperemia, which was found in 19.1% (n = 4).
Conclusions : BTFC provided a significant reduction in IOP from baseline without changing any anterior ocular parameters in OAG and NTG patients.
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KEYWORD
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Bimatoprost, Timolol, Fixed combination drug, Intraocular pressure, Glaucoma
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