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KMID : 1813520170060020055
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Journal of the Korean Glaucoma Society
2017 Volume.6 No. 2 p.55 ~ p.62
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Altered T cell Immunity in Patients with Posner-Schlossmann Syndrome
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Choi Jin-A
Noh Seung-June
Paik Soon-Young
Park Chan-Kee
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Abstract
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Purpose : Herpes viruses have become increasingly recognized in Posner-Schlossmann syndrome (PSS). It is hypothesized that PSS is associated with immunological changes to antigenic stimulation. We investigated the changes in T cell immunity in patients with PSS.
Methods : In this prospective cross-sectional study, peripheral blood samples were obtained at the hypertensive phase with aqueous inflammation in study patients (n = 15), and during cataract surgery in controls (n = 11) from March 2014 to February 2015. All patients underwent a serological screening for IgGs against herpes simplex virus and cytomegalovirus. The counts of each T-cell subpopulation were determined via flow cytometry. The concentrations of inflammatory cytokines were measured using Luminex multiplex bead immunoassay.
Results : The baseline intraocular pressure of the PSS group was significantly higher than that of the control group (p < 0.001) and the corneal endothelial cell count in the PSS group was significantly lower than that of the control group (p < 0.001). The PSS group had a significantly lower absolute lymphocyte count (1,931 ± 325 cells/mm2) than the control group (2,328 ± 507 cells/mm2; p = 0.041) and reduced numbers of CD8+ T cells (p = 0.029). In the same group, the CD8+CD28? and CD8+CD57+ T cell numbers, indicating the T cell immunosenescence were marginally lower than in the control group (p = 0.085 and 0.085, respectively). Serum TGF-β1 levels was significantly lower in the PSS than the control group (p = 0.012).
Conclusions : PSS patients do not appear to exhibit typical immune aging. Rather, PSS seems to be associated with systemic immune activation and relative lymphopenia.
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KEYWORD
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Cytokines, Cytomegalovirus, Flow cytometry, Immunosenescence, Herpesviridae
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