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KMID : 1813520190080020063
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Journal of the Korean Glaucoma Society
2019 Volume.8 No. 2 p.63 ~ p.73
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The Correlation of Retinal Nerve Fiber Layer Curvature and Thickness in Glaucoma
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Jung Kyoung-In
Park Hae-Young Lopilly
Park Chan-Kee
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Abstract
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Purpose : To analyze the relationship between retinal nerve fiber layer (RNFL) curvature using a Heidelberg Retina Tomograph III (HRI III) and the RNFL thickness profile measured by optical coherence tomography (OCT).
Methods : In total, 122 eyes with definite glaucoma, 44 eyes with suspected glaucoma, and 42 healthy eyes were enrolled in this retrospective study. All participants underwent a comprehensive ocular examination, perimetry, confocal scanning laser ophthalmoscopy, and OCT. The RNFL curvature and RNFL thickness at each quadrant were compared among three groups. The ability to discriminate between definite and suspected glaucoma, and healthy eyes was determined based on the area under the receiver operating characteristics curves. The correlation between the RNFL curvature and RNFL thickness in four quadrants was analyzed using the Pearson correlation method.
Results : Horizontal RNFL curvature, which was more convex than vertical curvature in the normal control subjects, was substantially reduced with the progression of glaucoma. The horizontal RNFL curvature showed a positive correlation with the superior, inferior, and temporal RNFL thicknesses (p ≤ 0.001, <0.001, and 0.002; γ = 0.309, 0.327, and 0.210, respectively). In subjects with a localized RNFL defect in the inferior quadrant, the vertical curvature had a strong negative correlation with the inferior RNFL thickness (p = 0.029, γ = ?0.603).
Conclusions : Compared with the vertical RNFL curvature, the horizontal RNFL curvature showed a higher diagnostic ability to discriminate between healthy and glaucomatous eyes, and a positive correlation with some RNFL thickness profiles.
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KEYWORD
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Confocal scanning laser ophthalmoscopy, Optical coherence tomography, Retinal nerve fiber layer curvature, Retinal nerve fiber layer thickness
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