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KMID : 1813520200090010010
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Journal of the Korean Glaucoma Society
2020 Volume.9 No. 1 p.10 ~ p.16
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Efficacy and Patient Tolerability of Preservative-free Latanoprost in Korean Primary Open Angle Glaucoma Patients
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Kim Yong-Woo
Lee Seung-Chan
Wy Seo-Young
Bak Eun-Oo
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Abstract
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Purpose : To investigate the efficacy and patient tolerability of preservative-free (PF) latanoprost in Korean primary open-angle glaucoma (POAG) patients.
Methods : Sixty six eyes of 35 patients who were first diagnosed with POAG and usesd PF-latanoprost as the first treatment for intraocular pressure (IOP) lowering and other 35 eyes of 19 patients who switched their medication from preserved latanoprost to PF latanoprost were retrospectively chart reviewed. The IOP prior to the use of PF latanoprost were compared with those from post-treatment 1, 3, and 6 months, respectively. Subjective ocular symptoms reported by the patients were monitored at each visit.
Results : As a first IOP lowering treatment, IOP significantly decreased from 16.2 ± 3.0 mmHg (n = 66) to 13.2 ± 2.8 mmHg at post-treatment 1 month (n = 61, p < 0.001), 11.8 ± 2.5 mmHg at 3 months (n = 20, p < 0.001), and 13.2 ± 2.6 mmHg at 6 months (n = 41, p < 0.001), respectively. When switched from preserved latanoprost, IOP did not change compared to the baseline (n = 35, 13.3 ± 1.9 mmHg), at post-treatment 1 month (n = 13, 12.7 ± 1.4 mmHg, p = 0.23), 3 months (n = 22, 12.7 ± 2.0 mmHg, p = 0.24), and 6 months (n = 29, 12.6 ± 1.8 mmHg, p = 0.14), respectively. Four eyes (4.0%) had to change their medication due to ocular side effects (conjunctival discharge, blurred vision, and dryness), but the rest of the eyes were able to maintain the PF latanoprost. Four eyes (11.4%) reported improved stinging sensation after switch from preserved latanoprost to PF latanoprost.
Conclusion : PF latanoprost showed satisfactory and comparable IOP lowering effect compared to preserved latanoprost in Korean POAG patients. Although less than 6% of eyes complained of various ocular symptoms, 11.4% of eyes reported improvement of stinging sensation when switched from preserved eye-drops.
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KEYWORD
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Preservative-free, Latanoprost, Primary open angle Glaucoma, Efficacy, Patient tolerability
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