|
KMID : 1813520210100010001
|
|
Journal of the Korean Glaucoma Society
2021 Volume.10 No. 1 p.1 ~ p.7
|
|
|
Multiplex Cytokine Assay of Aqueous Humor in Patients with Normal Tension Glaucoma
|
|
Kim Kyoung-Nam
Park Kee-Sup
|
|
|
Abstract
|
|
|
Purpose : To search for aqueous cytokines of normal tension glaucoma patients that are significantly different from those of normal and other open-angle glaucoma patients.
Methods : Normal tension glaucoma patients (NTG, 14 patients) were included as the study group, and patients without glaucoma (normal control, 58 patients), primary open-angle glaucoma patients (POAG, 20 patients), and pseudoexfoliative glaucoma (PXF glaucoma, 10 patients) were included as controls. Before cataract surgery, the aqueous humor was collected through anterior puncture and a multiplex cytokine assay was performed. The concentration of cytokines was compared between the normal subjects and each glaucoma group.
Results : Transforming growth factor (TGF)-β1, TGF-β3, and interleukin-6 were not significantly different among normal control, NTG, and POAG, and were significantly higher in PXF glaucoma (p=0.007, p< 0.001, and p=0.046, respectively). TGF-β2 and CXCL10/interferon gamma inducible protein-10 did not show a significant difference among normal control, NTG, and PXF glaucoma, and were significantly higher in POAG (p=0.012 and p=0.003, respectively). Compared to the normal control or other glaucoma groups, there was no aqueous cytokine significantly higher or lower only in NTG.
Conclusions : There was no cytokines identified in NTG, which showed a significant change compared to normal subjects or other types of open-angle glaucoma.
|
|
|
KEYWORD
|
|
|
Cytokines, Exfoliation syndrome, Low tension glaucoma, Primary open angle glaucoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|