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KMID : 1813520220110010012
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Journal of the Korean Glaucoma Society
2022 Volume.11 No. 1 p.12 ~ p.20
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Long-term Changes of Retinal Nerve Fiber Layer Thickness in Superior Segmental Optic Nerve Hypoplasia
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Jang Mirinae
Park Ki-Ho
Kim Young-Kook
Jeoung Jin-Wook
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Abstract
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Purpose : To evaluate the long-term changes of retinal nerve fiber layer (RNFL) thickness in superior segmental optic nerve hypoplasia (SSOH).
Methods : In this retrospectively longitudinal observational study, patients with SSOH who could be observed for more than 5 years at the Glaucoma Clinic of Seoul National University Hospital were included. In the cases performed optical coherence tomography (OCT) examination 3 or more, using the guided progression analysis (GPA) program of OCT, the thickness change of the RNFL was analyzed. Two glaucoma specialists judged whether there were any significant changes in RNFL thickness and visual field tests. In addition, the percentage of change in the RNFL per unit period was measured by calculating the change of the RNFL for each OCT examination interval.
Results : A total of 23 patients and 33 eyes were analyzed and average follow up period was 85.2 ± 23.3 months. According to the GPA of OCT, no progression was detected in 32 eyes (97.0%) and progression was determined by detection of superotemporal RNFL thinning in one eye (3.0%). Two specialists judged that there was no significant progression in these 33 eyes. The rate of RNFL thickness decrease per year was -0.306%/year (p = 0.008) in the average RNFL and -0.400%/year (p = 0.015) in the superior quadrant RNFL.
Conclusions : In the patients with SSOH, the rates of RNFL thickness were within the normal ranges according to age. However, long-term follow-up for glaucoma screening will be necessary for patients with SSOH.
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KEYWORD
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Optical coherence tomography, Optic nerve hypoplasia
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