|
KMID : 1813520220110020092
|
|
Journal of the Korean Glaucoma Society
2022 Volume.11 No. 2 p.92 ~ p.101
|
|
|
Ophthalmic Factors Affecting Visual Field Improvement in Parasellar Tumor
|
|
Lee Seung-Yeop
Park Han-Seok
Ahn Jae-Hong
|
|
|
Abstract
|
|
|
Purpose : To determine the prognostic value of preoperative visual field (VF) and optical coherence tomography (OCT) measurement in VF outcomes of patients diagnosed with parasellar tumors.
Methods : In this retrospective longitudinal study, structural and functional parameters of the eyes of patients with parasellar tumors who underwent a transsphenoidal approach were analyzed using VF and OCT trials before and after the surgical procedure. VF parameters include foveal threshold (FT), mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI). Spectral-domain OCT parameters were peripapillary retinal nerve fiber layer thickness (pRNFL) and macular ganglion cell-inner plexiform layer complex thickness (mGCIPL). The post-operative VF change were grouped into group A with normal VF preoperatively, group B with recovered VF impairment postoperatively, and group C with unrecovered VF impairment postoperatively.
Results : Seventy-six eyes of 38 patients were analyzed (32 eyes in group A, 28 eyes in group B, and 16 eyes in group C). The mean duration of symptom before surgery was 8.3 months, and the mean tumor volume was 11.95 cm3. The preoperative VFI of each group was 97.9%, 67.8%, and 47.2%; MD was 0.03, -9.88, and -15.59 dB; FT was 37.25, 27.93, and 25.06 dB, respectively. Preoperative average pRNFL was 95.16, 87.11, and 98.63 μm, average mGCIPL was 80.84, 74.21, and 64.38 μm, and minimal mGCIPL was 77.13, 66.57, and 54.38 μm, respectively. There was a significant difference between group B and C in VFI, average mGCIPL, minimal mGCIPL, and some sectors of mGCIPL (superior, superonasal, inferonasal, and inferior). Preoperative ocular parameters (FT, VFI, MD, PSD, pRNFL, and mGCIPL) were analyzed by univariate logistic regression analysis and VFI, MD, and mGCIPL parameters were significantly associated with favorable VF outcomes (p < 0.05). Only minimal mGCIPL was significant by multivariate logistic regression analysis (p = 0.001).
Conclusions : In patients with sellar region tumor, preoperative mGCIPL thickness showed stronger association with VF improvement after the surgery than other preoperative functional and structural parameters measured by VF test and OCT including pRNFL thickness.
|
|
|
KEYWORD
|
|
|
Optical coherence tomography, Pituitary neoplasms, Visual fields
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|