KMID : 4412620160220010013
|
|
Clinical Hypertension 2016 Volume.22 No. 1 p.13 ~ p.13
|
|
The role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment
|
|
Hwang Hyo-Sang
Ko Kwang-Pil Kim Myeong-Gun Kim Si-Hun Moon Jeong-Geun Chung Wook-Jin Shin Mi-Seung Han Seung-Hwan
|
|
Abstract
|
|
|
Background: Subjects with abnormal metabolic conditions had increased risk for cardiovascular disease. We investigated the role of abnormal metabolic conditions on arterial stiffness in healthy subjects with no drug treatment.
Methods: A total 601 subjects (age 48.7?¡¾?11.8 years, male 46.2 %, hypertension 19.1 %) were enrolled. Major cardiovascular risk factors, metabolic conditions and parameters (pre-diabetes, diabetes mellitus, metabolic syndrome, fasting blood sugar (FBS), glycated hemoglobin), lipid profiles, hsCRP, and brachial ankle pulse wave velocity (baPWV) were measured.
Results: Subjects with metabolic syndrome (n?=?200) had higher baPWV than in subjects without metabolic syndrome (n?=?401) even after adjustments for age, sex and presence of hypertension (1435.9?¡¾?212.2 vs. 1336.5?¡¾?225.0 cm/sec, p?0.001). The differences of baPWV among normal FBS, prediabetes and diabetes mellitus groups are significant (P for trend?=?0.036) by multivariate analysis (adjustments for age, sex, office systolic blood pressure). Subjects with diabetes mellitus (n?=?30) had higher baPWV than in subjects with normal FBS (n?=?384, 1525?¡¾?267.1 vs. 1341.5?¡¾?224.1 cm/sec, P?=?0.016 adjustments for age, sex, office systolic blood pressure). BaPWV in subjects with prediabetes (n?=?187) was slightly higher, but not statistically significant than in subjects with normal FBS (P?=?0.377). Of interest, FBS was one of the independent predictors for increased baPWV (¥â?=?0.809, 95 % CI 0.222-1.397, p?=?0.007) by multivariate analysis.
Conclusions: Subjects with abnormal metabolic conditions have increased arterial stiffness independent of age and BP which may contribute to the development of cardiovascular disease.
|
|
KEYWORD
|
|
Cardiovascular disease, Arterial stiffness, Metabolic syndrome, Diabetes mellitus
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|