KMID : 4412620170230010027
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Clinical Hypertension 2017 Volume.23 No. 1 p.27 ~ p.27
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Amlodipine Vs. hydrochlorothiazide: is there any disparity in its antihypertensive effect or not?
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Jonnalagadda Venu Gopal
Choudhary Kanchan Matety Vijay Kranti
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Abstract
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We have read the article ¡°Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor blocker on 24-h central blood pressure and vascular hemodynamic parameters in hypertensive patients: study design for a multicenter, double-blinded, active controlled, phase 4, randomized trial¡± by GC Oh., et al. and found it quite interesting to learn the testing of effectiveness between amlodipine and hydrochlorothiazide in combination with losartan. After 4 weeks of therapy, non-responders were exposed for dose titration of losartan/amlodipine 100/5 mg daily or losartan/hydrochlorothiazide 100/25 mg daily. However, authors didn¡¯t increase in the amlodipine dose from 5 to 10 mg from randomization. However, as per literature both drugs are non-significant in their blood pressure lowering effect. The clarification on above point will further allay the efficacy concerns of clinicians and result in wider usage of future published data.
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KEYWORD
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Hypertension, Calcium channel blockers, Thiazide diuretics, ARB blockers
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