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KMID : 4412620190250010018
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Clinical Hypertension
2019 Volume.25 No. 1 p.18 ~ p.18
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The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function
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Kim Hack-Lyoung
Lim Woo-Hyun
Seo Jae-Bin
Kim Sang-Hyun
Zo Zoo-Hee
Kim Myung-A
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Abstract
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Background: This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function.
Methods: A total of 77 subjects (64.5?±?10.8?years, 67.5% females) without documented cardiovascular disease were prospectively recruited. All subjects underwent transthoracic echocardiography, baPWV and noninvasive measurement of CBP on the same day.
Results: In simple linear correlation analyses, neither baPWV nor CBP was associated with LV mass index or relative wall thickness (P?>?0.05 for each). Although baPWV significantly correlated with septal e´ velocity in simple linear correlation analyses (r?=?0.258, P?=?0.025), the significance was lost after controlling for potential confounder (P?=?0.881). In simple linear correlation analyses, central systolic blood pressure (CSBP) and central pulse pressure (CPP) significantly correlated with both septal e´ velocity or E/e´ (P??0.05 for each). After controlling for confounders, including age, sex and body mass index, CSBP correlated with septal e´ velocity (β?=???0.258, P?=?0.025), but not with E/e´ (P?=?0.074). CPP correlated with both septal e´ velocity (β?=???0.300, P?=?0.014) and E/e´ (β?=?0.428, P?=?0.002) in the same multivariable model.
Conclusions: In subjects without documented cardiovascular disease, CSBP and CPP may be more strongly associated with LV diastolic function than baPWV. Further studies with a larger sample size are needed to confirm our results.
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KEYWORD
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Arterial stiffness, Central blood pressure, Diastolic function, Left ventricle, Morphology
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