KMID : 4412620200260010020
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Clinical Hypertension 2020 Volume.26 No. 1 p.20 ~ p.20
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High serum uric acid within the normal range is a useful predictor of hypertension among Japanese community-dwelling elderly women
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Kawamoto Ryuichi
Ninomiya Daisuke Akase Taichi Asuka Kikuchi Kumagi Teru
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Abstract
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Background: The risk associated with serum uric acid (SUA) levels when within the normal range is unknown. This study aims to examine whether SUA within the normal range is a predictor of hypertension.
Methods: The subjects comprised 704 men aged 71?¡¾?9 (mean?¡¾?standard deviation) years and 946 women aged 70?¡¾?8?years recruited for a survey at the community based annual medical check-up. The main outcome was the presence of hypertension (antihypertensive medication and/or having SBP ¡Ã140?mmHg and/or DBP ¡Ã90?mmHg).
Results: At baseline, 467 (66.3%) men and 608 (64.3%) women had hypertension. Comparing to lowest quartile in women (SUA-1, uric acid 4.1?mg/dL), the unadjusted odds ratios (ORs) [95% confidence interval (CI)] for hypertension of SUA-2 (4.1 to 4.7?mg/dL), SUA-3 (4.8 to 5.4?mg/dL), and SUA-4 (¡Ã5.5?mg/dL) were 1.11 (0.78?1.59), 1.75 (1.20?2.55), and 1.89 (1.30?2.77), respectively. These associations were apparent even after adjustments for age, but ORs were attenuated after adjusting for all confounding factors. During a follow-up of 3.0?years, there were 35 (24.0%) hypertension cases in men and 51 (20.8%) in women. In women only, a significant association between increased SUA categories and incidence of hypertension was observed, and the multivariate-ORs (95% (CI) for incident hypertension of SUA-3 (4.5?5.2?mg/dL) and SUA-4 (¡Ã5.3?mg/dL) were 2.23 (0.81?6.11) and 3.84 (1.36?10.8), respectively.
Conclusions: These results suggest that baseline SUA within the normal range could be an important predictor for incidence of hypertension in Japanese community-dwelling elderly women.
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KEYWORD
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Serum uric acid, Hypertension, Risk factor, Women, Community-dwelling person
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