It is considered that HWA(febrile) symptom in Oriental medicine includes the hypertension and cause of arteriosclorosis.
To study the effectiveness on Cheong Sim Hwan(CH), Cheong Sim Tang(CTAC) and Ga Mi Cheong Sim Tang(KCTDE), rabbits were used in this experiment and the effectiveness of . Cheong Sim Tang(CTA) to the normal blood prossure and action to the TBA level of liver in-creased by CCI4 administration, and the effectiveness of Cheong Sim Hwan in TBA level of liver, lipid metabolism and analgesic effectiveness were experimented. And further Cheong Sim Tang with Coptis japonica Makino(CTA), fine branches of Coptis japonica Makino(CTB), Picrorrhizae Rhizoma(CTC), CTA plus Scutellariae Radix(KCTD), and KCTD plus Rhei Undulati Rhizoma(KCTE) were comparatively experimented to the effect in the TBA level of liver. Following results were obtained on this trial. 1. The effectiveness in blood pressure The effectiveness in normal blood pressure by administration Cheong Sim Tang(CTA) was increased by increasing the dosages of medicine but showed transient decreasing of the blood pressure. 2. The effectiveness in TBA level of liver Cheong Sim Hwan(CH) showed significant values in the TBA level, but Cheong Sim Tang (CIA, CTB, CTC, KCTD and KCTE) showed similar effectiveness. KCTD showed combined actions but KCTE did not reveal any combined action. 3. The effectiveness of lipid metabolism. 1) By administration Cheong Sim Hwan(CH), total cholesterol in serum increased by cholesterol administration was decreased rapidly than the control group. 2) Total serum triglyceride dropped nearly to normal level like that of total cholesterol. 3) Serum phospholipid showed higher level at the beginning than the control group but later decreased rapidly with significant values. 4) Serum -lipoprotein was slightly and rapidly decreased but it didn´t show any significant value until 22nd day and decreased very significantly from 26th day. 4. The analgesic effectiveness
Analgesic effectiveness changed by the dosages of Cheong Sim Hwan(CH) and revealed highly significant values.
By the above experimental results, it is suggested that these herbal medicine would be highly applicable to cerebrovascular accident, hypertension, arteriosclerosis, hyper-lipidosis and pain. And it is still considered that the conception of HWA reducing action (a*f`FAEj) in Oriental medicine is mutually related to the conception with dropping high blood pressure into normotension.
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