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KMID : 0352319810040000203
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Journal of KyungHee Oriental Medicine College
1981 Volume.4 No. 0 p.203 ~ p.208
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The Effect of Bigi-Hwan against Liver Damage in CCI₄ induced Albino-Rat
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Seo Jeong-Joo
Ahn Kyoo-Suk
Moon Jun-Jeon
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Abstract
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The results on treatmental activity of the Bigi-Hwan aqueous condensed solution (BHACS) against carbontetrachloride (CCl4) induced liver damage in the rat are described. The samples were found to display the high level of remedial activity producing significant lowering of serum glutamic pyruvic transaminase (S-GPT), serum glutamic oxaloacetic transaminase (S-GOT) alkaline phosphatase (AQP), lactic dehydrogenase (´DH) and leucineaminopeptidase (LAP) at a daily dose of 0.9m1/200g. 1. The SGOT activity in CCl4-poisoned rat was decreased after 48 hours by admin-istration of the BHACS. It was observed significantly in the statistical view point. 2. All of the trial groups showed the tendency of a remarkable decrease than the control group and revealed a high significance in S-GOT activity. Twice of a
daily dose (Sample II) showed a remarkable decrease. 3. In case of AQP activity of the experimental groups compared with the control group showed the remarkable decrease and revealed a high significant. 4. LDH activity of the sample groups compared with the control group, showed the tendency of the considerable decre ase and revealed statistical value. The effect of three kinds of experimental groups are found to similar to that of S-GOT. 5. The trial groups showed a remarkable decrease than the control group and revealed a high significant in S-LAP activity. 6. According to the above mentioned results, We consider that Bigi-Hwan have the curative effects for the liver diseases.
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