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KMID : 0352319820050000087
Journal of KyungHee Oriental Medicine College
1982 Volume.5 No. 0 p.87 ~ p.102
Effects of Changyeontang on the Gastric Ulcer in Rats


Abstract
The Changyeontang using gastric ulcer are composed Atractylis Rhizoma, Coptidis Rhizoma, Aurantii nobilis Pericarpium, Pinelliae Tuber, Heolen, Massa Medicata Fermentata, Evodiae Fructus, Amomi Semen, Glycyrrhizae Radix and Zingiberis Rhizoma. This studies were undertaken in an attempt to investigate the effects of Changyeontang on the Shay¢¥s ulceration, and gastric ulcer induced by aspirin, indomethacin and serotonin in rats. The experimental animals were divided into five groups and treated as follows:. The control group was administered physiological saline solution: the A group was administered decoction of parched ¢¥Changyeontang: the B group was administered decoction of unparched Changyeontang: the C group was administered extracts of parched Changyeontang: the D group was administered extracts of unparched Changyeontang.
The following results were obtained:
1. Secretion of gastric juice and gastric acid, and pepsin activities in gastric juice of rats were inhibited significantly by the administration of Changyeontang.
2. Decoction and extracts of Changyeontang showed inhibiting effect on the Shay¢¥s ulceration, and gastric ulcer induced by aspirin, indomethacin and serotonin in rats.
3. Increased contents of plasma-gastrin of rats on the Shay¢¥s ulceration, aspirin, indomethacin and serotonin induced gastric ulcers, were decreased significantly by the administration of Changyeontang.
4. Anti-ulcerative effect of decoction of Changyeontang was not statistically significant compared with the administered group of extract of Changyeontang.
5. Anti-ulcerative effect of parched Changyeontang was not statistically significant compared with the administered group of unparched Changyeontang. It is concluded that the anti-ulcerative effect of Changyeontang against the
Shay¢¥s ulceration, and gastric ulcer induced by aspirin, indomethacin and serotonin
seems to inhibit gastrin secretion and cholinergic action.
KEYWORD
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