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KMID : 0352319820050000209
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Journal of KyungHee Oriental Medicine College
1982 Volume.5 No. 0 p.209 ~ p.225
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Studies on Anticonvulsive, Analgesic, Antipyretic, Antiinflammatory and Antiulceratice Effect of Jakyagkamchotang in Experomental Animals
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Abstract
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The Jakyagkamchotang using abdominal pain and convulsion of pediatric diseases are composed of Glycyrrhizae Radix and Paeoniae Radix alba. This study was undertaken to investigate the effects of Jakyagkamchotang and parched Jakyagkamchotang on anticonvulsive, analgesic, antipyretic, anti-inflammatory and anl:iulcerative actions, and motility of isolated intestine of mice.
The following results were obtained:
1. Both Jakyagkamchotang and parched Jakyagkamchotang showed anticonvulsive effect against convulsion induced by strychnine.
2. Jakyagkamchotang and parched Jakyagkamchotang also showed antipyresis and analgesic effects.
3. Anti-inflammatory effect was showed markedly by the administration of water extract of Jakyagkamchotang and parched Jakyagkamchotang.
4. Isolated intestine of mice was relaxed with the treatment of Jakyagkamchotang and parched Jakyagkamchotang, and intestinal contraction induced by BaC12 and acetylcholine was also inhibited.
5. The water extracts of Jakyagkamchotang, and parched Jakyagkamchotang were significantly inhibited Shay´s ulceration in rats.
It is concluded that the Jakyagkamchotang seems to effective aginast abdominal pain, spasmodic diseases and gastric ulcer.
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