It has been known that Gentianae macrophyllae Radix is reputed to be effective in removal of "Pungseub" and "Heoyeol", and to be analgesic. Since ancient times, however, there have been many examples of substituting Lycoctoni Radix for Gentianae macrophyllae Radix. for that reason, this experiment was conducted to compare the diuretic, analgesic, anti-inflammatory, anti-pyretic, and anti-bacterial effect, and the toxicity of Lycoctoni Radix with those of Gentianae macrophyllae Radix. The results obtained in this work were summerized as follows: 1. In the test of acute toxicity, Lycoctoni Radix was found to be toxic in com- parison to Gentianae macrophyllae Radix which was found to be non-toxic. 2. Both herbs were found to be diuretic and Gentianae macrophyllae Radix was more effective than the other.
3. Both herbs were to be ineffective for the blood pressure and respiration. 4. Lycoctoni Radix was found to be more analgesic than the other. 5. Gentianae macrophyllae Radix was found to be more anti-inflammatory of the two and both demonstrated anti-pyretic effect. 6. Anti-bacterial effect was detected only in Lycoctoni Radix. It is concluded that Gentianae macrophyllae Radix has mild diuretic, analgesic, anti-inflammatory and anti-pyretic effect, but Lycoctoni Radix, due to its toxicity, can not be substituted for Gentianae macrophyllae Radix.
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