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KMID : 0352319850080000331
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Journal of KyungHee Oriental Medicine College
1985 Volume.8 No. 0 p.331 ~ p.345
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Experimental Studies on the Effect of Chungsimjihwangtang in Ischemic Heart Disease, Hypertension and Lipid Metabolism
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張二洙/Chang, Yee Su
金永錫/裵京燮/李京燮/具本泓/Kim, Young Suk/Bai, Hyong Sup/Lee, Kyung Sup/Koo, Bon Hong
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Abstract
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In order to study the clinical effectiveness of Chungsimjihwangtang on heart disease, hypertension and artherosclerosis, studies were performed to detect the drug effects on the rats of endotoxin-induced ischemic heart disease and. spontaneously hypertensive rats, and rabbits of cholesterol-induced hyperlipemia.
The following results were obtained.
1) In the rats of endotoxin- induced ischemic hearts, Chungsimjihwangtang result in the decrease of serum fibronogen levels and blood platelet count, the extension of prothrombin time and the increase of serum F.D.P. level.
2) Chungsimjihwangtang got the blood pressure to show a fall in the spontaneously hypertensive rats.
3) Chungsimjihwangtang prevented the increase of cholesterol, triglyceride, phospholipid and free fatty acid levels in serum of the rats of cholesterol- induced hyperlipemia rats.
4) The dried extract of Chungsimjihwangtang showed better result on every test than the mixture of simple dried extract of the composed drugs of the prescription.
With the generalization of the above-mentioned experimental results, it is thought that Chungsimjihwangtang will be for sure efficacious for the treatment of the ischemic heart disease, hypertension and artherosclerosis.
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