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KMID : 0352319980210010319
Journal of KyungHee Oriental Medicine College
1998 Volume.21 No. 1 p.319 ~ p.330
The role of the hypothalamic arcuate nucleus in the analgesia action in rats
Ro Shik

Choi Yong-Tae
Abstract
Electrical stimulation of the hypothalamic arcuate nucleus(HARN) has been shown to have an analgesic effect in rats. It was demonstrated that the HARN played an important role in mediating acupuncture analgesia, especially electroacupuncture analgesia with low-frequency. Furthermore, it has been suggested that such a role could be different between anteromedial and posterior parts of the HARN in performing the acupuncture analgesia.
The role of the HARN in the acupuncture analgesia was usually experimented by using the tail flick reflex. The present study investigated the effects of stimulation of the HARN on the jaw-opening reflex at various stimulation sites and conditions. The digastric electromyography (dEMG) was elicited by electrical stimulation of the tooth-pulp(a single square wave, for a duration of 0.3 ms, with a frequency of 0.5 Hz, and intensity of 1.5 times threshold).
Both ipsilateral and contralateral electrical stimulation produced a marked suppression of the dEMG and it recovered to the pre-stimulating level within about 10 min. There were no significantly different analgesic effect between the anteromedial and the posterior parts of the HARN stimulation. The high-frequency(100Hz) stimulation of the HARN induced a stronger analgesic effect than low-frequency stimulation(3Hz). More than 300§Ë intencity produced a potent suppression of the dEMG. The longer stimulation time did not produce a longer post-effect, as the 30 sec stimulation time was more effective than the 5 min stimulation.
From the results, it can be concluded that the proper stimulation of the HARN produces analgesic effect on the jaw-opening reflex induced by tooth-pulp stimulation as well as on the tail flick test, however, in this study the difference of the analgesic effect between the stimulation sites were not shown as on tail flick test.
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