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KMID : 0352319980210010361
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Journal of KyungHee Oriental Medicine College
1998 Volume.21 No. 1 p.361 ~ p.374
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The Experimental study on Anti-inflammatory and Analgesic effect of Akebia Caulis herb-acupuncture
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Chung Won-Jae
Choi Do-Young
Ahn Byoung-Choul
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Abstract
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In order to study the anti-inflammatory and analgesic effect of Akebia Caulis herb-acupuncture, the experimental groups were divided into 4 groups : Control group (group injected with normal saline herb-acupuncture). Sample Ⅰ (group injected with Akebiae Caulis herb-acupuncture 500mg/kg), Sample Ⅱ(group injected with Akebiae Caulis herb-acupuncture 1000mg/kg) and Sample Ⅲ(group injected with indomethacin 20mg/kg or aminopyrine 100mg/kg. And each group was injected into both loci of Chok-samni(ST36) by herb-acupuncture.
We measured the rat hind paw edema induced by Adjuvant, the mice paw edema induced by carrageenin, the Leukocyte Emigration into the CMC air-Pouch of rat. Vascular Permeability induced by Acetic acid in mice, the Writhing Syndrome induced by Acetic acid in mice, Heat-induced Pain Threshold in mice and Hydrolysis of Casein by Trypsin in vitro.
The results were as followed :
1. The mice paw edema induced by carrageenin was significantly decreased in 1000mg/kg herb-acupuncture group as compared with the control group.
2. The rat hind paw edema induced by Adjuvant was significantly decreased in herb-acupuncture groups as compared with the control group. But the effect on the Serum Iron and Copper contents in rat statistically has no significance.
3. The level of Leukocyte Emigration into the CMC air-Pouch of rat was significantly decreased in herb-acupuncture groups as compared with the control group. Especially in 1000mg/kg herb-acupuncture group the level was similar to the indomethacin-injected group.
4. The level of Vascular Permeability induced by Acetic acid in mice was significantly decreased in 1000mg/kg herb-acupuncture group as compared with the control group, but not in 500mg/kg herb-acupuncture group.
5. The level of Writhing Syndrome induced by Acetic acid in mice was significantly decreased in 1000mg/kg herb-acupuncture group as compared with the control group. And the level of Heat-induced Pain Threshold in mice was significantly decreased in 1000mg/kg herb-acupuncture group as compared with the control group.
6. The level of Hydrolysis of Casein by Trypsin in vitro was significantly decreased in high concentration herb-acupuncture group as compared with low concentration herb-acupuncture group, so the effect depended on the concentration of herb-acupuncture.
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