In order to study the effect of Morindae Radixv(÷éн) for IVF in mice, we studied the effect of the medium of Morindae Radix in vitro developmental effect of mouse embryos. And we observed the effect of Morindae Radix on the ovulation rate, on the production rate of zygotes, on the in vitro developmental effect of mouse embryos, on the rate of in vitro fertilization and culture, and on the sexual hormonal level, after administered the drug in oral. The results were following.
1. The medium of Morindae Radix was significantly ineffective in vitro development of 1-cell embryos.
2. The ovulation rate of Morindae Radix, especially admisistrated qd. in every other day for 6 days was ineffective.
3. After the drug administered, the production rate of zygotes and the in vitro developmental effect of mouse embryos were decreased.
4. Compared with the control group, the rate of number of embryos developed to blastocyst in vitro fertilization and culture was increased a little.
5. Compared with the control group, the levels of serum FSH and Progesterone in the mouse were increased after Morindae Radix administered.
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