We induced brain ischemia using middle cerebral artery occlusion(MCAo) and studied the results of walking initiation and circling test, posture reflex test, water bath swimming test to characterize the motor dysfunction and establish the model of stroke by MCAo for oriental medicine.
Analysis of total rotation angle during 1 min. swimming showed significant motor dysfunction in occlusion group(3hrs, 6hrs, 9hrs, 24hrs after MCAo).
Analysis of rectal rotation number during 1 min. swimming showed significant
difference between control group and occlusion group(3hrs, 6hrs, 9hrs, 24hrs after MCAo).
Analysis of posture reflex test showed significant difference between control group and occlusion group(3hrs, 6hrs, 9hrs, 24hrs, after MCAo).
Significant motor dysfunctions are shown at start time in 24hrs, at inner circle time and outer circle time in 9hrs, 24hrs, at contalaterl or ipsilateral circling number or 180°turn in 3hrs, 6hrs, 9hrs, 24hrs during walking initiation and circling test.
Results revealed that brain ischemia by intraluminal method was good at stroke model for oriental medicine which chiefly reveals motor dysfunction by paralysis of one side and behavior index suggested in this article could be used as a useful index for assessment of motor dysfunction.
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