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KMID : 0352319990220010185
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Journal of KyungHee Oriental Medicine College
1999 Volume.22 No. 1 p.185 ~ p.202
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A Study on the Effects of Pyungwee-san in the Movement of Gastrointestinal Smooth Muscles, Anticatharsis, and Central Nervous System
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Kim Yun-Kwan
Ryu Bong-Ha
Park Dong-Won
Ryu Gi-Won
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Abstract
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The aim of this experimental study was to investigate the effects of Pyungwee-san samples on the movement of astrointestinal smooth muscles, anticatharsis, and central nervous system by using rats or mice.
Samples were divided into five groups : Sample-Ⅰ : Pyungwee-san(Atractylodes Rhizoma, Aurantii Nobils Pericarpium, Magnoliae Cortex and Glycyrrhizae Radix), sample-Ⅱ : Exclusion of Atractylodes Rhizoma from Pyungwee-san, Sample-Ⅲ : Exclusion of Aurantii Nobils Pericarpium from Pyungwee-san, Sample-Ⅳ: Exclusion of Magnoliae Cortex Rhizoma from Pyungwee-san, Sample-Ⅴ : Exclusion of Glycyrrhizae Radix from Pyungwee-san.
The results were as follows :
1. All samples showed inhibitory effect on the motility of the isolated ileum and relaxant effect on the contracted ileum induced by acetylcholine chloride and barium chloride, these effects were dependent on their concentrations.
2. All samples in which sample-Ⅲ was exclude showed inhibitory effect on the motility of the rat fundus strip and relaxant effect on the contracted fundus strip induced by acetylcholine chloride and barium chloride, these effects were dependent on their concentrations.
3. Anticathartic effect of Pyungwee-san samples was appeared in sample-Ⅰ, sample-Ⅳ, sample-Ⅴ after drug medication in caster oil induced diarrhea.
4. Analgestic effect of Pyungwee-san samples on inhibition of writhing syndrome by acetic acid was recognized in sample-Ⅰ, sample-Ⅱ, sample-Ⅴ.
5. Effect of Pyungwee-san samples prolonging the hypnotic duration by pentobarbital-Na in Mice was shown in sample-Ⅱ, sample-Ⅲ.
6. Effect of Pyungwee-san samples on prolonging the time to death induced by strychnine was appeared in sample-Ⅳ(p<0.001).
7. Effect of Pyungwee-san samples on Picrotoxin-induced Convulsion in mice was appeared in all samples and on prolonging the time to death induced by strychnine was appeared in sample-Ⅱ, sample-Ⅲ, sample-Ⅳ.
8. Effect of Pyungwee-san samples on Caffeine-induced Convulsion in mice was appeared in sample-Ⅰ(p<0.01), sample-Ⅳ(p<0.05).
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KEYWORD
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