In order to study was anti-allergic effects of Paljin-tang and Gamipaljin-tang, the vascular permeability response induced intradermal histamine & serotonin, homologous PCA and contact dermatitis by picryl chlolide were observed, and to study the immune response, delayed type hypersensitivity, hemagglutinin titer, hemolysin titer, rosette forming cells, phagocytic activity for immune response, lymphocyte transformation, productivity of Interleukin-2 in immune depressed mice by methotrexate were measured.
The results were obtained as follows :
1. The vascular permealbility responses to intradermal histamine and serotonin were significantly decreased as compared with control group in Gamipaljin-tang group.
2. In the homologous PCA, Gamipaljin-tang group was revealed significant decrease as compared with control group.
3. In the delayed type hypersensitivity responses to Picryl Chloride, Paljin-tang and Gamipaljin-tang groups were proved significant inhibitory effect as compared with control group.
4. Body weight was significantly increased as compared with control group in Paljin-tang and Gamipaljin-tang groups.
5. Delayed type hypersensitivity was significantly increased as compared with control group in Paljin-tang and Gamipaljin-tang groups.
6. Hemagglutinin titer was significantly increased as compared with control group in Paljin-tang group.
7. Hemolysin titer was significantly increased as compared with control group in Paljin-tang group.
8. Rosette forming cells was significantly increased as compared with control group in Paljin-tang and Gamipaljin-tang groups.
9. Phagocytic activity for immune response was slightly increased in Paljin-tang and Gamipaljin-tang groups without significance as compared with control group.
10. Lymphocyte transformation was significantly increased as compared with control group in Paljin-tang and Gamipaljin-tang groups.
11. Productivity of Interleukin-2 was significantly increased as compared with control group in Paljin-tang and Gamipaljin-tang groups.
According to the above results, it could be suggested that Paljin-tang and Gamipaljin-tang have anti-allergic and enhance immunity.
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