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KMID : 0354619940060010037
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Journal Dankook Dental Research Institute
1994 Volume.6 No. 1 p.37 ~ p.55
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THE EXPERIMENTAL STUDY ON THE LYOPHILIZED ALLOGENEIC TMJ DISC TRANSPLANTATION IN THE RABBIT
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Abstract
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In occasions when articular disk is perforated or removed, restrfng injured or resected disk and a normal bony structure of the joint is undoubtedly a choice of treatment. In such a case, various disk substitutes are being used, but considering the advantages, dlsadvantages and long-term prognosis of individual substitute materials for disc, there is still no ideal materlal closely resembling the original disk both functionally and histologically. Besides, owing to the unique characteristic disk in anatomic structure & tissue nature, material closely resembling the disk should be able to withstand the masticatory force and play a active role in jaw movement. From this point of view, lyophilized allogeneic articular disk could be the superior substitute in various aspects only if the problem of immunologic rejection can be solved. There upon the author grafted lyephilized allogeneic articular disks into the left TMJ of 15 male rabbits weighing about 3.0 kg. And also autogenous articular disks harvested from
left TMJ were placed into the defects of right articular disk and histological observation was performed to evaluate the efficiency of the lyophilized allogeneic TMJ disk as a disk substiaite.
The results were as follows ;
1. In groups where lyophilized allogeneic disks were grafted most of fhe graft material resorbed in early stage whereas the one adjacent to synovial tissue relatively longer. From the 3rd week, synovial tissue proliferated actively, and chondrocyte like cell appeared in remaining graft material adjacent to synovial tissue at 6th week.
2. While lyophilized allogeneic disk was resorbed, new disk having similar form to that of the flbrous cartilage which grew from adjacent synovial membrane was partially formed owing to its action as space maintainer & matrix instead of removed disk.
3. New disk tissue formed from a mold of lyophilized allogeneic disk was functionally superior enough to protect the articular surfaces of the articular fossa & condyle well histologically.
4. Autogenous articular disk demonstrated a similar histological picture to normal articular disk at 1 week after In this manner autogenous disk was shown to be superior to lyophilized allogeneic disk at early stage, but lyophilized allogeneic disk substitute was also evaluated to have suffcient efficiency as articular disk substitute because it was transformed into the new disk with time.
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