|
KMID : 0354619940060020381
|
|
Journal Dankook Dental Research Institute
1994 Volume.6 No. 2 p.381 ~ p.390
|
|
|
An Influence Of Capsaicinoids On Release Of Neurotransmitter In The Trigeminal Sensory Nucleus
|
|
|
|
|
Abstract
|
|
|
Excitatory amino acids(EAA) neurotransmitters, glutamate and aspartate, play a role in transmission of primary afferents of orofacial pain in trigeminal spinal sensory nucleus.
This experiment was performed to study the role of capsaicin, its derivative and analogue on release of glutamate and aspartate from trigeminal spinal sensory nucleus in slice of brainstem. Horizontal slice of caudal brainstem of rat prepared and
perfused with modified Krebs-Ringer solution in brain slice chamber.
Release of EAAs was induced by apsaicin(μM), KR-25018(10μM) and shogaol(10μM), which was added to perfusion solution to observe the changes in EAAs release and effect of ruthenium red and capsazepine on the capsicinoids. And then EAAs being
determined by HPLC.
Release of glutamate and aspartate from horizontal slice of caudal brainstem was increased by capsaicin and KR-25018. But shogaol had not affected on release of EAA. Effect of capsaicin and KR-25018 was partially blocked by capsaicin antagonists,
ruthenium red and capsazepin in vitro.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|