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KMID : 0354619950070010033
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Journal Dankook Dental Research Institute
1995 Volume.7 No. 1 p.33 ~ p.42
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Experimental Study on the S-100 Protein Change of Condylar Head after Unilateral Diskectomy in Rabbit
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Abstract
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S-100 protein is cRefly in neuroectoderrnal origin tissue of human body. For example it exists in odontogenic epithelial cell, melanocyte in skin, chondrocyte in cartilage, and it is involved in calcium metabolism.
The purpose of this study was In observe the change of cell proliferation of condylar head after unilateral diskectomized by anti S-100 protein antibody method. 20 rabbits of 3.0 Kg body weight(control;5, experimental;15) were used and diskectomized in left side of experimental group.
According to the sacrification schedule, excised TMJ of control and experimental group was fixed, dicalcified and immunohistochemically stained by LSAB method.
S-1OO protein positive cells were observed under the microscope accordillg to stainability.
The results were as follows,
1. Histopatholigic features showed increased hyperplasia of hypertrophic zone, but decreased narrownss of errosive zone in surgical site.
2. S-100 protein positive cells could be seen in the hypertrophic zone of control group. In experiment group, they were seen in hyalinized chondrocyte at 1 week, from 3 to 6 weeks they were found at the borderline of proliferative and hypertrophic zone.
3. In 8 weeks of expermental group, positive reaction was appeared in upper portion of hypertrophic and erosive zone. In 10 weeks of experimental group, slight positive reaction in hypertrophic zone was similar to control group.
From the above fkndings, we can observe the change of undifferentiated cell intn chondrocyte at early stage of diskectomized condyle head. After 10 weeks, narrowing of proliferative zone and widening of hypertrophic zone and cartilagenous cell migration into suhchondral bone could be seen.
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