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KMID : 0358719640010010047
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Korean Journal of Biochemistry
1964 Volume.1 No. 1 p.47 ~ p.50
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Pharmacological and Biochemical Effect of Allicin
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金允洙/Pak, Soo Yun
金利植/金炳勳/朴秀淵/Kim, Yoon Soo/Kim, Byung Hoon/Kim, Ei Sik
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Abstract
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Sgihara isolated a. volatile substance (allicin) from garlic and demonstrated that allicin had a hypotensive effect in vivo and had an´ inhibiting effect on the isolated intestinal and the auricular movements in vitro. He thought without any conclusive evidence
that this hypotensive effect is due to the central nerve depression.
On the other hand, Song seperated a nonvolatile hypotensive substance, Garlic Extract, from the garlic. The present studies were undertaken to reinvestigate the effect of allicin on blood pressure and on the isolated intestinal and the auricular movements.
In anesthetized rabbit, allicin produced a marked hypotensive effect abruptly after intravenously administration. This effect was slightly diminished at repeated subsequent injection. The hypotensive effect of akin was not blocked by antihistamic drug, pyribenzamine. The isolated intestinal movement was slightly and temporarily excited at the begining at low concentrations of allicin but was inhibited strongly at high concentration. The isolated auricular movement was also inhibited by allicin. The allicin showed the effect of increasing the permeability of capillaries in rat skin to trypan blue. Pyribenzamine did not block this effect. Allicin showed markedly inhibiting effect on oxygen consumption by liver slide in rat. So it may be said that histamine is not re-leased by allicin, that increased permeability of capillaries in rat skin to trypan blue is due to the effect of allicin itself, and that inhibiting effect of allicin on the isolated intestinal and auricular movement due to inhibiting effect of allicin on cell metabolism.
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