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KMID : 0359020080370040259
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Korean Journal of Gastrointestinal Endoscopy
2008 Volume.37 No. 4 p.259 ~ p.264
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Comparison of the Efficacy of Bismuth Containing PPI-based Quadruple Therapy with PPI-based Triple Therapy Only as First-line Treatment for Helicobacter pylori Infection
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Jo Hyun-Jin
Jeong Sook-Hyang
Kim Na-Young
Lee Dong-Ho
Jung Hyun-Chae
Song In-Sung
Kim Jin-Wook
Lee Sang-Hyub
Park Young-Soo
Kang Seung-Joo
Kim Mi-Na
Kim Su-Hyun
Park Jin-Myung
Choi Mun-Sun
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Abstract
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Background/Aims: In recent years, increasing antimicrobial resistance has resulted in falling eradication rates
with standard therapies. To overcome the falling eradication rates, rescue therapy have been suggested to be
used. However, there is no surveillance of using bismuthbased regimen as first line Helicobacter pylori eradication therapy in Korea. This study aimed to assess the efficacy of bismuth containing PPI-based quadruple therapy as a first line treatment.
Background/Aims: In recent years, increasing antimicrobial resistance has resulted in falling eradication rates
with standard therapies. To overcome the falling eradication rates, rescue therapy have been suggested to be used. However, there is no surveillance of using bismuthbased regimen as first line Helicobacter pylori eradication therapy in Korea. This study aimed to assess the efficacy of bismuth containing PPI-based quadruple therapy as a first line treatment.
Results: There was no significant difference in eradication rates between bismuth containing and noncontaining
group. However, in PUD, the eradication rate of PACB (95.2%) is somewhat higher than that of PAC (86.2%) without statistical significance.
Conclusions: In PUD, Future study designed with a double-blind controlled large scale might reveal that PPI-based standard quadruple therapy containing a bismuth is superior to the standard triple therapy. (Korean J Gastrointest Endosc 2008;37: 259-264)
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KEYWORD
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Helicobacter pylori, Bismuth, Helicobacter pylori, First-line treatment, Bismuth, Peptic ulcer disease
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