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KMID : 0359020100410010010
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Korean Journal of Gastrointestinal Endoscopy
2010 Volume.41 No. 1 p.10 ~ p.15
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A Clinical Usefulness of Premedication with Hyoscine N-butyl Bromide in Colonoscopy
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Kim Eun-Ok
Lee Suck-Ho
Kim Duk-Su
Lee Chang-Kyun
Lee Tae-Hoon
Chung Il-Kwun
Park Sang-Heum
Kim Sun-Joo
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Abstract
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BACKGROUND/AIMS: We conducted a prospective, randomized, double-blinded, placebo-controlled trial to investigate the effect of hyoscine-N-butyl bromide during colonoscopy.
METHODS: A total of 133 patients undergoing colonoscopy were randomized to receive either 20 mg of hyoscine-N-butyl bromide (n=70) or normal saline solution (n=63) via intramuscular injection as premedication.
RESULTS: The mean cecal intubation time and withdrawal time in the hyoscine-N-butyl bromide group were significantly shorter than those of the control group (5.26+/-2.78 min vs. 6.74+/-4.89 min; p=0.032, 5.42+/-1.54 min vs. 6.18+/-2.54 min; p=0.038, each). The spasm grade in the hyoscine-N-butyl bromide group was significantly lower than that of the control group (p<0.001). No significant differences were found in the polyp detection rate (15.7% vs. 28.6%; p=0.073) and adenoma detection rate (10.0% vs. 15.9%; p=0.311). Difficulty of colonoscopy for the endoscopists and nurses (p=0.853; p=0.732), the patient’s comfort (p=0.891) and the patient’s willingness to repeat colonoscopy (85.7% vs. 82.5%; p=0.932) were also similar in both groups.
CONCLUSIONS: Premedication with intramuscularly administered hyoscine-N-butyl bromide do not demonstrate any additional benefits except reducing the colonoscopy insertion time.
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KEYWORD
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Colonoscopy, Premedication, Antispasmodics, Hyoscine-N-butyl bromide
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