KMID : 0359020100410060360
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Korean Journal of Gastrointestinal Endoscopy 2010 Volume.41 No. 6 p.360 ~ p.363
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A Case of Rectal Cancer in a Patient with X-linked Agammagloubulinemia
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Jeon Byung-Jun
Kim San-Wook Ko Kang-Suk Kim Seong-Hun Kim In-Hee Lee Seung-Ok Lee Soo-Teik Kim Dae-Ghon
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Abstract
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X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disorder caused by germline mutation of the Bruton tyrosine kinase (BTK) gene. Most of the patients diagnosed X-LA suffer from recurrent infections of the respiratory and gastrointestinal tracts. Increased risk of malignancy in X-LA patients include lymphoma, gastric cancer, colorectal cancer. We report a case of 32-years-old male patient with X-linked agammagolbulinemia and rectal cancer. Agammaglobulinemia was diagnosed at 13 years old. He underwent colonoscopy for hematochezia. An ulceroinfiltrative mass was found during colonscopy and biopsy revealed moderately differentiated adenocarcinoma. Subsequently, he underwent a anterior resection.
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KEYWORD
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X-linked agammaglobulinemia, Rectal cancer
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