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KMID : 0359020110420020074
Korean Journal of Gastrointestinal Endoscopy
2011 Volume.42 No. 2 p.74 ~ p.82
Regression of Hyperplastic Gastric Polyp after Helicobacter pylori Eradication
Lim Sang-Ah

Yun Jae-Won
Yoon Dae-Woong
Choi Won-Jae
Kim Seung-Han
Choe Jung-Wan
Kim Mi-Na
Kang Eun-Joo
Park Jong-Jae
Joo Moon-Kyung
Lee Beom-Jae
Park Young-Tae
Lee Sang-Woo
Park Jong-Tae
Abstract
Background/Aims: Recent studies have suggested that the eradication of Helicobacter pylori (Hp) may lead to the regression of hyperplastic polyps (HPPs) in the stomach. We evaluated the sizes of HPPs after Hp eradication and we also compared the clinical parameters between the regression and non-regression groups.

Methods: We enrolled 187 patients who had HPPs in the stomach. The polyps were measured by using biopsy forceps, and the endoscopically observed changes of the polyps were assessed by two endoscopists.

Results: Total regression was observed in 68 patients of the eradicated group and in 6 patients in the non-eradicated group (42.5% vs. 22.2%, respectively, p<0.05). The non regression rate was significantly higher for the non-eradicated group than that for the eradicated group (33% vs. 10%, respectively, p<0.05). Comparing between the regression and non-regression groups, the incidence of polyps that were smaller than 10 mm in size and sessile was significantly higher in the regression group. Hp eradication was the only significant predictor of regression.

Conclusions : Hp eradication could be a therapeutic option for Hp positive-hyperplastic gastric polyps, and especially for those that are less than 10 mm in size and sessile.
KEYWORD
Hyperplastic gastric polyp, Helicobacter pylori, Eradication, Regression, Predictive factor
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