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KMID : 0359020110420030161
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Korean Journal of Gastrointestinal Endoscopy
2011 Volume.42 No. 3 p.161 ~ p.164
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Methylene Blue Solution-induced Acute Esophageal Mucosal Injury: First Case Report
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Ko Ock-Bae
Kim Do-Hoon
Kang Jeong-Min
Jung Hwoon-Yong
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Abstract
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Methylene blue (MB) based chromoendoscopy has been used for more than a decade to increase detection rates of specialized intestinal metaplasia, dysplasia, and esophageal adenocarcinoma. It is also used to detect anastomotic leakage after an operation. A 67-year-old man with no previous medical problems had complaints of jaundice and weight loss for 2 months. He was diagnosed with a Klatskin tumor and was referred to our hospital. An initial esophagogastroduodenoscopy (EGD) was performed before the operation. No abnormality was observed in the esophagus. MB solution was infused via an L-tube to check for leakage in the anastomosis. Subepithelial hemorrhagic and edematous mucosal changes with friability and a bluish mucosal discoloration were noted 2 days later from the mid to lower esophagus on EGD. Nine months later, an EGD revealed an unremarkable esophageal mucosa. MB solution is considered safe; however, a large volume or high concentration of MB solution might be harmful.
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KEYWORD
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Methylene blue, Esophagus, Injury
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