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KMID : 0359020110440020109
Korean Journal of Gastrointestinal Endoscopy
2011 Volume.44 No. 2 p.109 ~ p.115
Comparison on the Efficacy of Disinfectants Used in Automated Endoscope Reprocessors: PHMB-DBAC versus Orthophthalaldehyde
Kim Sun-Young

Lee Hong-Sik
Hyun Jong-Jin
Seo Min-Ho
Yim Sun-Young
Oh Ha-Young
Kim Hye-Sook
Keum Bo-Ra
Seo Yeon-Seok
Kim Yong-Sik
Jeen Yoon-Tae
Chun Hoon-Jai
Um Soon-Ho
Kim Chang-Duck
Ryu Ho-Sang
Abstract
Background/Aims: Since endoscopes are reusable apparatus classified as semicritical item, thorough reprocessing to achieve high-level disinfection is of utmost importance to prevent spread of infection. To improve disinfection efficacy and safety, disinfectants and endoscope reprocessors are continuously evolving. This study aimed to compare the efficacy of the combination of polyhexamethylenebiguanide hydrochloride-alkyldimethylbenzylammonium chloride (PHMB-DBAC) and orthophthalaldehyde (OPA) used respectively in ultrasonographic cleaning incorporated automated endoscope reprocessors: COOLENDO (APEX Korea) or OER-A (Olympus Optical).

Methods: A total of 86 flexible upper endoscopes were randomly reprocessed with either COOLENDO/PHMB-DBAC or OER-A/OPA. Culture samplings were done at two sites (endoscope tip and working channel) which were later incubated on blood agar plate. Bacterial colonies were counted and identified.

Results: The culture-positive rate at the endoscope tip and working channel was 0% and 2.33% for COOLENDO/PHMB-DBAC and 4.65% and 0% for OER-A/OPA. Staphylococcus hominis was cultured from one endoscope reprocessed with COOLENDO/PHMB-DBAC and Pseudomonas putida was isolated from two endoscopes reprocessed with OER-A/OPA.

Conclusion: The reprocessing efficacy of COOLENDO/PHMB-DBAC was non-inferior to that of OER-A/OPA (p=0.032; confidence interval, -0.042 to 0.042). During the study period, significant side effect of PHMB-DBAC was not observed.
KEYWORD
Endoscope reprocessing, Disinfectants, High-level disinfection
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학술진흥재단(KCI) KoreaMed 대한의학회 회원