|
KMID : 0359020130460040390
|
|
Korean Journal of Gastrointestinal Endoscopy
2013 Volume.46 No. 4 p.390 ~ p.394
|
|
|
Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted
|
|
Talreja Jayant P.
Ellen Kristi
Schmitt Timothy
DeGaetani Marisa
Gaidhane Monica
Kahaleh Michel
|
|
|
Abstract
|
|
|
Background/Aims: Photodynamic therapy (PDT) in unresectable cholangiocarcinoma has been associated with improved survival. We report a single tertiary care center experience over the past 6 years.
Methods: Fifty-five patients with unresectable cholangiocarcinoma received PDT between 2004 and 2010. Plastic stents were placed after PDT to prevent cholangitis.
Results: Twenty-seven patients (49%) showed Bismuth type IV, 22 (41%) showed Bismuth type III, and six (10%) showed Bismuth type I and II. Twenty patients (37%) received chemotherapy and radiation therapy, five (9%) received chemotherapy only; and one (2%) received radiation therapy only. Mean number of PDT sessions was 1.9±1.5 sessions (range, 1 to 9). Mean survival duration was 293±266 days (median, 190; range, 25 to 1,332). PDT related complications included three (5%) facial burn, three (5%) photosensitivity, and two (3%) rash. Kaplan-Meier analysis comparing the survival means of patients who received PDT and chemotherapy/radiation therapy (median survival 257 days; 95% confidence interval [CI], 166 to 528) versus who received PDT only (median survival 183 days; 95% CI, 129 to 224) showed no significant difference (log-rank p=0.20).
Conclusions: PDT has a measurable impact on survival in unresectable cholangiocarcinoma but requires aggressive stenting posttherapy.
|
|
|
KEYWORD
|
|
|
Photodynamic therapy, Cholangiocarcinoma, Single operator choledochoscopy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|