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KMID : 0359020130460060611
Korean Journal of Gastrointestinal Endoscopy
2013 Volume.46 No. 6 p.611 ~ p.619
Application of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Imaging Mass Spectrometry (MALDI-TOF IMS) for Premalignant Gastrointestinal Lesions
Ko Kwang-Hyun

Kwon Chang-Il
Park So-Hye
Han Na-Young
Lee Hoo-Keun
Kim Eun-Hee
Hahm Ki-Baik
Abstract
Imaging mass spectrometry (IMS) is currently receiving large attention from the mass spectrometric community, although its use is not yet well known in the clinic. As matrix-assisted laser desorption/ionization time-of-flight (MALDI)-IMS can show the biomolecular changes in cells as well as tissues, it can be an ideal tool for biomedical diagnostics as well as the molecular diagnosis of clinical specimens, especially aimed at the prompt detection of premalignant lesions much earlier before overt mass formation, or for obtaining histologic clues from endoscopic biopsy. Besides its use for pathologic diagnosis, MALDI-IMS is also a powerful tool for the detection and localization of drugs, proteins, and lipids in tissue. Measurement of parameters that define and control the implications, challenges, and opportunities associated with the application of IMS to biomedical tissue studies might be feasible through a deep understanding of mass spectrometry. In this focused review series, new insights into the molecular processes relevant to IMS as well as other field applications are introduced.
KEYWORD
Spectrometry, mass, matrix-assisted laser desorption-ionization, Imaging mass spectrometer, Biological markers, Premalignant gastrointestinal lesions, Chemoprevention
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