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KMID : 0359319860260010031
Korean Journal of Veterinary Research
1986 Volume.26 No. 1 p.31 ~ p.37
Study on Antiestrogenic Effects of Tamoxifen in Immature Rat Uterus



Abstract
The present study has been carried out to elucidate the antiestrogenic effects of tamoxifen on RNA and protein synthesis in uteri of immature rats.
Immature female Sprague-Dawley rats were allocated into 4 groups and injected with 5㎍ of estradiol-17β, 50㎍ of tamoxifen, a combination of both, or vehicle only subcutaneously three times with an interval of 24 hours respectively.
The specific activities of ³H-uridine incorporation into uterine RNA and those of ³H-leucine incorporation into uterine protein were measured before and 1,3,6,12,24,48 and 72 hours after the above treatments.
The results obtained were summarized as follows;
1. Tamoxifen itself increased RNA synthesis an hour after treatment(169.18% of control), but it´s specific activity was reduced to control level after 3 hours. Tamoxifen inhibited significantly (p<0.01) the activity of RNA synthesis of estradiol-17β.
2. The increasing rate of protein synthesis was lower in tamoxifen treated group than that in estradiol-17βtreated group. While the rate was steadily increased up to 357.4% of control by estradiol-17β in 72 hours, tamoxifen itself failed to increase the rate after 24 hours and significantly (p< 0.01) inhibited the activity of estradiol-17β(-167.4%).
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학술진흥재단(KCI)