KMID : 0359319920320010007
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Korean Journal of Veterinary Research 1992 Volume.32 No. 1 p.7 ~ p.13
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Relaxation of P2 - purinoceptor on isolated renal artery of rabbit
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Abstract
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To elucidate the action of P©ü-purinoceptor, effects of adenosine triphosphate(ATP) and perivascular nerve stimulation were investigated from polygraph in the isolated renal artery of rabbit
1. ATP caused the relaxation on the precontraction wi2h noradrenaline(lO¥ìM)on the presene and absence of endothelium in the isolated renal artery of rabbit, the relaoative response was increased between 0.1 and 301¥ìM on dose-dependent manner.
2. The relaxative response induced by ATP(l0¥ìM) on precontraction with noradrenaline(l0¥ìM) was blocked by the pretreatment with reactive blue 2(10¥ìM).
3. ATP inhibited the contractile response by perivascular nerve stimulation(0.3§Â, 80V, 50Hz, 1 sec), the inhibitory action was blocked by the pretreatment with 8-phenyltheophylline(l0¥ìM).
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