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KMID : 0359319920320040635
Korean Journal of Veterinary Research
1992 Volume.32 No. 4 p.635 ~ p.640
Spontaneous lingual papillomas in Fischer 344 rats


Abstract
Two cases of lingual masses were observed among 500 Fischer 344 ( F344 ) rats which were used as control and treated animals in a 2 year carcinogenicity study in Toxicology Research Center, Korea Research Institute of Chemical Technology. The masses grossly appeared as tan, pedunculated. fungiform on the dorsal aspect of the base of the tongues. They were approximately 1.5×1.2×0.3㎝ in size. The microscopic features consisted of acanthosis, hyperkeratosis, papillary projection with connective tissue cores and multifocal chronic active inflammation with hair shafts. The results observed support the epigenetic mechanism of tumorigenesis which is caused by Physical stimuli of foreign bodies. Both of the masses were diagnosed as papillomas with the incidence rate of 0.4%(1/250) in each sex on the basis of the gross and microscopic features.
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학술진흥재단(KCI)