잠시만 기다려 주세요. 로딩중입니다.
KMID : 0359319930330030407
Korean Journal of Veterinary Research
1993 Volume.33 No. 3 p.407 ~ p.417
Effect of Bupleurum falcatum extract on cellular immune responses




Abstract
Bupleurum falcatum has been used for treatment of inflammation, jaundice, influenza and hepatitis as a traditional orient folk medicine. This experiment was carried out to evaluate the effect of B falcatum extract on cellular immune responses in vivo and in vitro. Antigen binding cell(ABC)assay, antibody production, Arthus and delayed-type hypersensitivity(DTH) reaction against sheep erythrocytes(SRBC) were very depressed in B falcatum extract treated group in vivo The growth of Staphylococcus aureus in brain heart infusion(BHI) broth containing B falcatum extract was remarkably inhibited. Otherwise, that of Salmonella typhyimurium was not significantly increased in vivo. When B falcatum extract pretreated mice were intraperitoneally(IP) injected S typhimunrium and S aureus, respectively, the number of bacteria in peritoneal exudates were time dependent declination compared with chose of control, and the weight of spleen and the number of macrophage migration into peritoneal cavity have no difference from those of untreated control. B falcatum extract gradually increased phagocytic activities of peritoneal macrophage against Candida albicans time and dose dependently, and was not significant production of migration inhibiotory factor(MIF). But migration abilities of normal leucocytes in B falcatum extract pretreated group were decreased dose dependently. When B falcatum extract was IP administered, these data indicate that B falcatum extract increases level of serum coticosterone. Therefore, B falcatum extract was indirectly mediated in immune system by serum coticosterone having relation to immunosuppression. These results lead to the conclusion that B falcatum extract acts as a trigger or regulator of cellular immune responses in immune system.
KEYWORD
FullTexts / Linksout information
Listed journal information
학술진흥재단(KCI)